OHSU algorithm could be useful in maintaining safe levels of glucose

Researchers and physicians at Oregon Health & Science University, using artificial intelligence and automated monitoring, have designed a method to help people with type 1 diabetes better manage their glucose levels.

The research was published in the journal Nature Metabolism.

"Our system design is unique," said lead author Nichole Tyler, an M.D.-Ph.D. student in the OHSU School of Medicine. "We designed the AI algorithm entirely using a mathematical simulator, and yet when the algorithm was validated on real-world data from people with type 1 diabetes at OHSU, it generated recommendations that were highly similar to recommendations from endocrinologists."

That's significant because the people with diabetes typically go three to six months between appointments with their endocrinologist.

In that time, they can be at risk of dangerous complications if glucose levels in their blood rise too high or fall too low. People with type 1 diabetes do not produce their own insulin, so they must take it continuously through the day using an insulin pump or through multiple daily injections. The algorithm developed by OHSU scientists uses data collected from a continuous glucose monitor and wireless insulin pens to provide guidance on adjustments.

25 giugno dalle ore 10:00 alle 12.30

Il Consiglio Nazionale dei Geologi, in collaborazione con l'Ordine dei Geologi della Regione Calabria, organizza il 25 giugno dalle ore 10 alle 12.30 il Convegno online "Caratterizzazione, Progettazione ed Esecuzione di interventi di risanamento ambientale e discariche abusive: aspetti giuridici e tecnici".

Al centro del convegno ci saranno i temi dello smaltimento illecito di rifiuti, spesso pericolosi e della lotta alle discariche abusive su tutto il territorio nazionale, in particolar modo si prenderà in considerazione la questione dei rifiuti speciali abbandonati in Calabria. Tra i punti che saranno affrontati anche la messa in sicurezza e la bonifica dei siti inquinati oltre che il risanamento ambientale di aree particolarmente degradate. Inoltre si parlerà anche del ruolo, delle funzioni e della gestione degli appalti nelle gare di lavori pubblici.

Il Presidente GISE Giuseppe Tarantini: “Con l’epidemia c’è stato un crollo degli accessi, dovuto alla paura dei cittadini, ma anche alla riorganizzazione degli ospedali. Dobbiamo ripartire dalle Regioni per offrire subito e in maniera omogenea i dispositivi medici più innovativi. Così riduciamo le liste d’attesa”.

Roma, 17 giugno 2020 – “Dobbiamo lavorare ad una nuova fase, investendo nel recupero degli interventi salvavita, per evitare ai pazienti con gravi patologie cardiovascolari di allungare ulteriormente il tempo di attesa. Ripartiamo dal confronto con Governo e Regioni per discutere, partendo dai dati, potenziali soluzioni da offrire su tutto il territorio nazionale, ridurre le liste d’attesa e aumentare la qualità della vita delle persone”. Questo il messaggio di Giuseppe Tarantini, Presidente della Società Italiana di Cardiologia Interventistica alla vigilia del Thinkheart 2020, il convegno che il GISE (già Gruppo Italiano Studi Emodinamici) dedica ai dati di attività di cardiologia diagnostica e interventistica.

For more than four decades, fluoxetine has been used to treat depression and other mental health problems in humans. Now the drug could also help combat Covid-19. A study conducted by virologists and chemists at the University of Würzburg has shown that fluoxetine significantly inhibits viral replication of SARS-CoV-2. The scientists believe that this makes it suitable for the early treatment of infected patients who are at a higher risk for severe illness.

The study is led by Professor Jochen Bodem and his team from the Institute of Virology and Immunobiology at the University of Würzburg with support from Professor Jürgen Seibel from the Institute of Organic Chemistry. The scientists have published the results of their study on the bioRxiv preprint server.

Changes in the entire brain (left) and hippocampus (middle) are evident in these images shot during the course of a mouse's life. Green shows the protein PSD95 and cyan is the protein SAP102.

Why do children think and behave differently from adults? Why do we become forgetful in old age? Researchers have shown for the first time how the connections between the brain’s nerve cells, the synapses, change over the course of life, and likely affect our processing of information.

As you age, you may have correctly suspected that your brain is changing along with the rest of your body. In a study published in Science last week, researchers reported the unprecedented mapping of molecular changes in the brains of 50 mice over time – down to the individual synapses. These changes in molecular make-up are distributed throughout the regions of the brain and they likely influence our cognitive development and susceptibility to brain disorders as we advance in age, says the study’s co-author, Erik Fransén, professor at KTH Royal Institute of Technology’s and a researcher with SciLifeLab.

“We have looked at molecules of billions of individual synapses across the brain in miceagedfrom newborn to old,” Fransén says. “We find a remarkable variation in synapse types. Different brain regions have different types and this mix of types changes as we age.”