Osteoblast-cells of a mouse growing on 3D matrices and developed from the waste of agri-food industry (Author: Milagros Ramos, Ángeles Martín, Malcolm Yates and Violeta Zurdo (CTB-UPM y CSIC).

Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to aging. A team of researchers from the Centre for Biomedical Technology at Universidad Politécnica de Madrid (CTB-UPM), in collaboration with Instituto de Ciencia de Materiales (ICMM-CSIC) and Institute of Catalysis and Petrochemistry (ICP-CSIC) from Spanish Council for Scientific Research (CSIC), have produced biocompatible materials from waste of the agri-food industry, specifically from the apple pomace resulting from the juice production.

Research shows surprising conclusions about fish numbers

We're all familiar with the idea of extreme events. Meteorologists keep us up to date on hurricanes, floods and high temperatures. Economists watch the stock market for signs of crashes or rallies. Researchers spend a lot of time trying to better predict these events, yet are often surprised by the outcomes. According to a new study in the journal Limnology & Oceanography Letters, when it comes to nature's extremes, nothing seems to beat what happens underwater. Scientists at the National Science Foundation (NSF) North Temperate Lakes Long-Term Ecological Research (LTER) site -- one of 28 NSF LTER sites -- are routinely measuring everything from water temperature to nutrient concentrations to fish populations in Wisconsin lakes.

Every tenth employee increases their alcohol consumption to risky levels at the time of retirement from full-time employment. However, the increase seems to be temporary as risky drinking often decreases during the retirement. For most pensioners, alcohol consumption remains below the risk levels before and after retirement. The results of the new Finnish study were published in the esteemed Addiction journal. Of retiring employees, 12 percent increased their risky drinking at the time of retirement. However, for most people, there was no change in risky level alcohol consumption around the time of retirement: 81 percent sustained healthy drinking during the follow-up, and in 7 percent of the participants risky drinking was constant, although they experienced a slow decline in risky level alcohol consumption after retirement. In the study, the levels for risky drinking were 24 units per week for men and 16 units for women, or passing out due to extreme alcohol consumption.

Polydom deficient mouse shows severe edema in skin and thoracic cavity (right). Wild-type mouse embryo is shown in left panel.

Lymphatic vessels form a circulatory system that plays an important role in controlling the amount of fluid in tissues, and allowing the immune system to identify and target threats. When the lymphatic system malfunctions, fluid accumulates in tissues, producing a condition known as edema. This can be fatal; for example, lung edema can cause respiratory arrest. The molecular mechanisms underlying lymphatic system development are not fully understood, with particular uncertainty surrounding the later stages of development, in which the primitive system is remodeled to produce a mature, functional lymphatic vasculature.

Examples of morph sequence stimuli from low intensity (left) to high intensity (right). From top to bottom; male adult angry sequence, female adult surprise sequence, male child happy sequence, female child sad sequence

Young people with autism spectrum conditions (ASC) have difficulties recognising and distinguishing between different facial expressions, according to research from one of the largest studies to look at emotion recognition in children and adolescents with ASC. The University of Bristol findings are published today [31 Mar 2017] in the Journal of Autism and Developmental Disorders. A team from Bristol’s School of Experimental Psychology aimed to find out whether six basic facial expressions differing in intensity are challenging for young people with autism to recognise.

Land snails are generally believed to be ground-dwelling creatures, preferring dark and humid places, like the forest floor, or a suburban garden. So why do we find some species of snails in the tops of trees, where it is relatively light and dry? Associate Professor Ikuyo Saeki from the University of Tsukuba, Japan and her colleagues from Hokkaido University and other institutions, have performed some fascinating research to find out why. Prof. Saeki wanted to know what drives animals to leave the ground, defying gravity to live in the tree tops. Is it because there are fewer predators, or less competition with other animals? Is there more, or better, food? Some studies suggest that tree-dwelling species live longer than ground dwellers, but this idea, along with the others, is not easy to test in a natural environment. That’s when Prof. Saeki and her colleagues decided to enlist the help of a Japanese tree-climbing land snail.

Bleached Acropora colony photographed in July 2015. A new study finds that a 2°C rise in the sea surface temperature of the South China Sea in June 2015 was amplified to produce a 6°C rise on the Dongsha Atoll, killing approximately 40 percent of the resident coral community. (Photo by Thomas DeCarlo, Woods Hole Oceanographic Institution)

In the South China Sea, a 2°C rise in the sea surface temperature in June 2015 was amplified to produce a 6°C rise on Dongsha Atoll, a shallow coral reef ecosystem, killing approximately 40 percent of the resident coral community according to a study published in Scientific Reports this week. Wind and waves churn the sea, flushing shallow-water coral reefs with seawater from the open ocean to help them stay cool. But according to new research from the Woods Hole Oceanographic Institution (WHOI), when the weather turns still and these natural cooling mechanisms subside, just a few degrees of ocean warming can prove lethal to the corals that live there.

Increasing the woody biomass supply sustainably, continuously and at acceptable prices is a huge challenge . It’s not always easy to see the wood from trees when dealing with complex challenges in energy policy. However, Europe is increasingly finding in its forests a significant source of renewable energy that could help the region move away from fossil fuel dependency. Known collectively as woody biomass, these by-products of forest management are also useful raw materials to be crafted into wood products, turned into energy or converted into mulch and erosion control materials.

During replication, the two strands are separated. Each strand of the original DNA molecule then serves as a template for the production of its complementary counterpart (Figure: Wikimedia Commons).

Analyzing DNA is useful for a number of vital applications. This includes diagnosis and monitoring of diseases, identification of criminals, and studying the function of a targeted segment of DNA. However, methods used for analyses often require more DNA than may be available in a typical sample. ‘Therefore, amplification is necessary, but not always straightforward. The most widely used amplification or photocopying method is the polymerase chain reaction (PCR). A new PCR method could help the amplification process, and thus develop robust assays that previously would not have been possible. Deoxyribonucleic acid (DNA) is a molecule found in the nucleus of cells and carries the 'instructions' for the development and functioning of living organisms. It is often compared to a set of blueprints since it contains the instructions needed to build cells. These instructions are divided into segments along a strand of DNA.

 
Il gruppo di ricerca dell'Università di Tor Vergata, guidato dalla Dr.ssa Francesca Gioia Klinger e coordinato dal Prof. Massimo De Felici ha scoperto una nuova funzione dell’ormone luteinizzante, LH, nella donna che potrebbe essere utilizzata per la preservazione della fertilità delle donne che si sottopongono a chemioterapia e prolungare la funzionalità dell’ovaio che termina con la menopausa. Fino ad oggi si pensava che le funzioni dell’LH, secreto dall’ipofisi, fossero nella donna in età fertile, l’induzione dell’ovulazione e il mantenimento del corpo luteo, necessario per le prime fasi di sviluppo dell’embrione. La ricerca in oggetto ha dimostrato che l’LH è in grado di difendere i follicoli primordiali (che contengono gli ovociti destinati ad essere ovulati e fecondati dopo un lungo processo di maturazione), dagli effetti deleteri di un noto chemioterapico, il cisplatino, utilizzato nelle terapie di diversi tipi di tumori, compresi quelli che più frequentemente colpiscono le donne, come il tumore della mammella. Di fatto, i ricercatori hanno trovato che mentre il trattamento con cisplatino distruggeva i follicoli primordiali e rendeva sterili topoline in età prepubere, quando il chemioterapico veniva somministrato insieme all’LH, la maggior parte dei follicoli primordiali non degenerava e le topoline raggiunta l’età adulta risultavano fertili. Il gruppo ha anche dimostrato che la causa della degenerazione dei follicoli è con ogni probabilità attribuibile ai danni che il cisplatino apporta al DNA dell’ovocita contenuto nei follicoli; l’LH stimolerebbe i meccanismi di riparo del DNA e allo stesso tempo bloccherebbe le vie di morte per apoptosi che il cisplatino attiva negli ovociti. Attraverso quali meccanismi l’LH svolga questa importante nuova funzione e se essa avvenga anche in ovaie umane, è quello che i ricercatori stanno attualmente investigando. Queste scoperte potrebbero portare allo sviluppo di una strategia di protezione della funzionalità ovarica più fisiologica per le giovani pazienti malate di cancro.